Benzylated and prenylated flavonoids from the root barks of Cudrania tricuspidata with pancreatic lipase inhibitory activity

Yang Hee Jo; Seon Beom Kim; Qing Liu; Jin Woo Lee; Bang Yeon Hwang; Mi Kyeong Lee

doi:10.1016/j.bmcl.2015.07.017

Benzylated and prenylated flavonoids from the root barks of Cudrania tricuspidata with pancreatic lipase inhibitory activity

Bioorg Med Chem Lett. 2015 Sep 1;25(17):3455-7. doi: 10.1016/j.bmcl.2015.07.017. Epub 2015 Jul 17.

Authors

Yang Hee Jo¹, Seon Beom Kim¹, Qing Liu¹, Jin Woo Lee¹, Bang Yeon Hwang¹, Mi Kyeong Lee²

Affiliations

¹ College of Pharmacy, Chungbuk National University, 1 Chungdae-ro, Seowon-gu, Cheongju 362-763, Republic of Korea.
² College of Pharmacy, Chungbuk National University, 1 Chungdae-ro, Seowon-gu, Cheongju 362-763, Republic of Korea. Electronic address: mklee@chungbuk.ac.kr.

PMID: 26227773
DOI: 10.1016/j.bmcl.2015.07.017

Abstract

A new benzylated and prenylated flavonone, cudracuspiflavanone A (17) were isolated from the roots of Cudrania tricuspidata (Moraceae), together with two chromones (1-2) and fourteen flavonoids (3-16). The structures of isolated compounds were determined on the basis of spectroscopic analysis. The absolute configuration was also defined by CD analysis. Among the isolated compounds, compounds 14 and 15 inhibited pancreatic lipase activity with an IC50 value of 9.0 and 6.5 μM, respectively.

Keywords: Cudracuspiflavanone A; Cudrania tricuspidata; Moraceae; Pancreatic lipase.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Biological Products
Flavonoids / chemistry*
Lipase / chemistry*
Molecular Structure
Moraceae / chemistry*
Obesity / drug therapy*
Pancreas / drug effects*
Plant Extracts / chemistry*

Substances

Biological Products
Flavonoids
Plant Extracts
Lipase